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Did RNA Replicate in Codon-Wise Manner during RNA Era?

Matti Pitkanen


It is possible to replicate unfolded RNA strands in Lab by using enzymes known as ribozymes, which are RNA counterparts of enzymes, which are amino-adic sequences. In the presence of folding the replication is however impossible. Since ribozymes are in general folded, they cannot thus catalyze their own replication in this manner.  It has been however discovered that the replication using RNA triplets - genetic codons - as basic unit can be carried out in laboratory even for the folded RNA strands and with rather low error rate. Also the ribozyme involved can thus replicate in codon-wise manner. For units longer than 3 nucleotides the replication becomes prone to errors. The TGD based model for the findings relies on the vision that there are several realizations of the counterparts of DNA, RNA, tRNA, and amino-acids and of the genetic code so that chemical code is only one particular realization. For the dark realization in terms of entangled dark proton triplets one cannot analyze the codons to triplets of ordered letters so that codon is the smallest unit. This motivates the proposal that RNA replication during RNA era happened in codon-wise manner and relied on pre-tRNA in which amino-acid catalyzed the addition of RNA of tRNA to RNA sequence. The crucial evolutionary step would have been analogous to the emergence of written language in which words decomposed into letters meaning a transition from RNA era to DNA era and DNA replication and transcription in a letter-wise fashion. At this step DNA and RNA polymerases and DNA helicase emerged. This picture is discussed from the point of view of the realization of the code in terms of 3-chords formed from dark photons. The 12-note scale forming the basis of model of bio-harmony based on 64 chord harmony emerges naturally.

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